abstract：:Modulation of insulin-dependent signaling is emerging as a valuable therapeutic tool to target neurodegeneration. In the brain, the activation of insulin receptors promotes cell growth, neuronal repair, and protection. Altered brain insulin signaling participates in the cognitive decline seen in Alzheimer's disease pa...

journal_title：Neurobiology of aging

authors： Bomba M,Granzotto A,Castelli V,Massetti N,Silvestri E,Canzoniero LMT,Cimini A,Sensi SL

更新日期：2018-04-01 00:00:00

abstract：:Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells activate the unfolded protein response (UPR), a signal transduction pathway that enforces adaptive p...

journal_title：Neurobiology of aging

authors： Gerakis Y,Hetz C

更新日期：2018-03-01 00:00:00

abstract：:Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand...

journal_title：Neurobiology of aging

authors： Bradburn S,McPhee J,Bagley L,Carroll M,Slevin M,Al-Shanti N,Barnouin Y,Hogrel JY,Pääsuke M,Gapeyeva H,Maier A,Sipilä S,Narici M,Robinson A,Mann D,Payton A,Pendleton N,Butler-Browne G,Murgatroyd C

更新日期：2018-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker degrees and patterns of Aβ deposition, glucose hypometabolism, and gray matter volume (GMV) reduction in 3 groups at risk of AD. In elderly...

journal_title：Neurobiology of aging

authors： Wirth M,Bejanin A,La Joie R,Arenaza-Urquijo EM,Gonneaud J,Landeau B,Perrotin A,Mézenge F,de La Sayette V,Desgranges B,Chételat G

更新日期：2018-03-01 00:00:00

abstract：:Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

journal_title：Neurobiology of aging

authors： Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

更新日期：2018-02-01 00:00:00

abstract：:We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarrier...

journal_title：Neurobiology of aging

authors： Galimberti D,Fumagalli GG,Fenoglio C,Cioffi SMG,Arighi A,Serpente M,Borroni B,Padovani A,Tagliavini F,Masellis M,Tartaglia MC,van Swieten J,Meeter L,Graff C,de Mendonça A,Bocchetta M,Rohrer JD,Scarpini E,Genetic FTD I

更新日期：2018-02-01 00:00:00

abstract：:Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

journal_title：Neurobiology of aging

authors： Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

更新日期：2018-02-01 00:00:00

abstract：:Loss-of-function caused by mutations in the parkin gene (PARK2) lead to early-onset familial Parkinson's disease. Recently, mechanistic studies proved the ability of parkin in regulating mitochondria homeostasis and microtubule (MT) stability. Looking at these systems during aging of PARK2 knockout mice, we found that...

journal_title：Neurobiology of aging

authors： Cartelli D,Amadeo A,Calogero AM,Casagrande FVM,De Gregorio C,Gioria M,Kuzumaki N,Costa I,Sassone J,Ciammola A,Hattori N,Okano H,Goldwurm S,Roybon L,Pezzoli G,Cappelletti G

更新日期：2018-01-01 00:00:00

abstract：:Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers m...

journal_title：Neurobiology of aging

authors： Rose C,Dorard E,Audrain M,Gorisse-Hussonnois L,Cartier N,Braudeau J,Allinquant B

更新日期：2018-01-01 00:00:00

abstract：:Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structur...

journal_title：Neurobiology of aging

authors： Zhao T,Sheng C,Bi Q,Niu W,Shu N,Han Y

更新日期：2017-11-01 00:00:00

abstract：:Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

journal_title：Neurobiology of aging

authors： Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

更新日期：2017-11-01 00:00:00

abstract：:Decline in cerebrovascular health complicates brain aging, and development of cerebral microbleeds (CMBs) is one of its prominent indicators. In a large sample of healthy adults (N = 251, age 18-78 years at baseline, 70% women), the contributions of chronological age and vascular health indicators to the risk of devel...

journal_title：Neurobiology of aging

authors： Daugherty AM,Raz N

更新日期：2017-11-01 00:00:00

abstract：:The brain mechanisms underlying the effect of intellectual enrichment may evolve along the normal aging Alzheimer's disease (AD) cognitive spectrum and may include both protective and compensatory mechanisms. We assessed the association between early intellectual enrichment (education, years) and average cortical flor...

journal_title：Neurobiology of aging

authors： Arenaza-Urquijo EM,Bejanin A,Gonneaud J,Wirth M,La Joie R,Mutlu J,Gaubert M,Landeau B,de la Sayette V,Eustache F,Chételat G

更新日期：2017-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20...

journal_title：Neurobiology of aging

authors： Edler MK,Sherwood CC,Meindl RS,Hopkins WD,Ely JJ,Erwin JM,Mufson EJ,Hof PR,Raghanti MA

更新日期：2017-11-01 00:00:00

abstract：:This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition...

journal_title：Neurobiology of aging

authors： Kang JM,Lee SY,Seo S,Jeong HJ,Woo SH,Lee H,Lee YB,Yeon BK,Shin DH,Park KH,Kang H,Okamura N,Furumoto S,Yanai K,Villemagne VL,Seong JK,Na DL,Ido T,Cho J,Lee KM,Noh Y

更新日期：2017-11-01 00:00:00

abstract：:Genetic variants are implicated in the development of amyotrophic lateral sclerosis (ALS), but it is unclear whether the burden of rare variants in ALS genes has an effect on survival. We performed whole genome sequencing on 8 familial ALS (FALS) patients with superoxide dismutase 1 (SOD1) mutation and whole exome seq...

journal_title：Neurobiology of aging

authors： Pang SY,Hsu JS,Teo KC,Li Y,Kung MHW,Cheah KSE,Chan D,Cheung KMC,Li M,Sham PC,Ho SL

更新日期：2017-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewe...

journal_title：Neurobiology of aging

authors： Sharma A,Kaut O,Pavlova A,Fröhlich H,Ahmad A,Schmitt I,El-Maarri O,Oldenburg J,Wüllner U

更新日期：2017-09-01 00:00:00

abstract：:We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD...

journal_title：Neurobiology of aging

authors： Yoshino H,Hirano M,Stoessl AJ,Imamichi Y,Ikeda A,Li Y,Funayama M,Yamada I,Nakamura Y,Sossi V,Farrer MJ,Nishioka K,Hattori N

更新日期：2017-09-01 00:00:00

abstract：:Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined f...

journal_title：Neurobiology of aging

authors： Qiu W,Guo X,Lin X,Yang Q,Zhang W,Zhang Y,Zuo L,Zhu Y,Li CR,Ma C,Luo X

更新日期：2017-09-01 00:00:00

abstract：:A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, ag...

journal_title：Neurobiology of aging

authors： Ibanez L,Dube U,Budde J,Black K,Medvedeva A,Davis AA,Perlmutter JS,Benitez BA,Cruchaga C

更新日期：2017-08-01 00:00:00

abstract：:The visual processing of complex motion is impaired in Alzheimer's disease (AD). However, it is unclear whether these impairments are biased toward the motion stream or part of a general disruption of global visual processing, given some reports of impaired static form processing in AD. Here, for the first time, we di...

journal_title：Neurobiology of aging

authors： Porter G,Wattam-Bell J,Bayer A,Haworth J,Braddick O,Atkinson J,Tales A

更新日期：2017-08-01 00:00:00

abstract：:Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the import...

journal_title：Neurobiology of aging

authors： Lee JH,Lee AJ,Dang LH,Pang D,Kisselev S,Krinsky-McHale SJ,Zigman WB,Luchsinger JA,Silverman W,Tycko B,Clark LN,Schupf N

更新日期：2017-08-01 00:00:00

abstract：:The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzh...

journal_title：Neurobiology of aging

authors： Viaña JNM,Vickers JC,Cook MJ,Gilbert F

更新日期：2017-08-01 00:00:00

abstract：:Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

journal_title：Neurobiology of aging

authors： Chan YM,Pianta MJ,Bode S,McKendrick AM

更新日期：2017-07-01 00:00:00

abstract：:Anticholinergic drug use is common in older adults and has been related to increased dementia risk. This suggests that users of these drugs may experience accelerated cognitive decline. So far, however, longitudinal data on this topic are absent and the available evidence is inconclusive with respect to effects on spe...

journal_title：Neurobiology of aging

authors： Papenberg G,Bäckman L,Fratiglioni L,Laukka EJ,Fastbom J,Johnell K

更新日期：2017-07-01 00:00:00

abstract：:Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, accordi...

journal_title：Neurobiology of aging

authors： Aziz AL,Giusiano B,Joubert S,Duprat L,Didic M,Gueriot C,Koric L,Boucraut J,Felician O,Ranjeva JP,Guedj E,Ceccaldi M

更新日期：2017-06-01 00:00:00

abstract：:Aging is accompanied by increased neuroinflammation, synaptic dysfunction, and cognitive deficits both in rodents and humans, yet the onset and progression of these deficits throughout the life span remain unknown. These aging-related deficits affect the quality of life and present challenges to our aging society. Her...

journal_title：Neurobiology of aging

authors： Rogers JT,Liu CC,Zhao N,Wang J,Putzke T,Yang L,Shinohara M,Fryer JD,Kanekiyo T,Bu G

更新日期：2017-05-01 00:00:00

abstract：:Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

journal_title：Neurobiology of aging

authors： Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

更新日期：2017-05-01 00:00:00

abstract：:To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-buil...

journal_title：Neurobiology of aging

authors： Sudre CH,Cardoso MJ,Frost C,Barnes J,Barkhof F,Fox N,Ourselin S,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2017-05-01 00:00:00

abstract：:Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

journal_title：Neurobiology of aging

authors： Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

更新日期：2017-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of motor neurons. To date, more than 20 genes have been implicated in ALS, and of these, the 2 most frequently mutated are the superoxide dismutase 1 (SOD1) gene and the chromosome 9 open reading frame 72 (C9ORF72) gene. In t...

journal_title：Neurobiology of aging

authors： Tripolszki K,Csányi B,Nagy D,Ratti A,Tiloca C,Silani V,Kereszty É,Török N,Vécsei L,Engelhardt JI,Klivényi P,Nagy N,Széll M

更新日期：2017-05-01 00:00:00

abstract：:Frontotemporal lobar degeneration is a neuropathological disorder that causes a variety of clinical syndromes including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal syndrome (CBS). FTD associated with parkinsonism occurs frequently as a result of mutations in the C9orf72 gene and als...

journal_title：Neurobiology of aging

authors： Gatto EM,Allegri RF,Da Prat G,Chrem Mendez P,Hanna DS,Dorschner MO,Surace EI,Zabetian CP,Mata IF

更新日期：2017-05-01 00:00:00

abstract：:In recent years, CHCHD2 and CHCHD10 mutations were reported to be associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), although with conflicting results in different populations. The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients wi...

journal_title：Neurobiology of aging

authors： Rubino E,Brusa L,Zhang M,Boschi S,Govone F,Vacca A,Gai A,Pinessi L,Lopiano L,Rogaeva E,Rainero I

更新日期：2017-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

journal_title：Neurobiology of aging

authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

更新日期：2017-05-01 00:00:00

abstract：:The use of biomarkers has been proposed for diagnosing Alzheimer's disease in recent criteria, but some biomarkers have not been sufficiently investigated to justify their routine clinical use. Here, we evaluate in a literature review the clinical validity of amyloid positron emission tomography (PET) imaging using a ...

journal_title：Neurobiology of aging

authors： Chiotis K,Saint-Aubert L,Boccardi M,Gietl A,Picco A,Varrone A,Garibotto V,Herholz K,Nobili F,Nordberg A,Geneva Task Force for the Roadmap of Alzheimer's Biomarkers.

更新日期：2017-04-01 00:00:00

abstract：:Mutations in TMEM230 have recently been associated to Parkinson's disease (PD). To further understand the role of this gene in the Caucasian population, we interrogated our large repository of next generation sequencing data from unrelated PD cases and controls, as well as multiplex families with autosomal dominant PD...

journal_title：Neurobiology of aging

authors： Giri A,Mok KY,Jansen I,Sharma M,Tesson C,Mangone G,Lesage S,Bras JM,Shulman JM,Sheerin UM,International Parkinson's Disease Consortium (IPDGC).,Díez-Fairen M,Pastor P,Martí MJ,Ezquerra M,Tolosa E,Correia-Guedes L,Ferrei

更新日期：2017-02-01 00:00:00

abstract：:Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory ...

journal_title：Neurobiology of aging

authors： Franzmeier N,Buerger K,Teipel S,Stern Y,Dichgans M,Ewers M,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2017-02-01 00:00:00

abstract：:Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male...

journal_title：Neurobiology of aging

authors： Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

更新日期：2017-01-01 00:00:00

abstract：:C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansio...

journal_title：Neurobiology of aging

authors： Kun-Rodrigues C,Ross OA,Orme T,Shepherd C,Parkkinen L,Darwent L,Hernandez D,Ansorge O,Clark LN,Honig LS,Marder K,Lemstra A,Scheltens P,van der Flier W,Louwersheimer E,Holstege H,Rogaeva E,St George-Hyslop P,Londos E,

更新日期：2017-01-01 00:00:00

abstract：:Lipid rafts are highly dynamic membrane microdomains intimately associated with cell signaling. Compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such Alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other typ...

journal_title：Neurobiology of aging

authors： Marin R,Fabelo N,Martín V,Garcia-Esparcia P,Ferrer I,Quinto-Alemany D,Díaz M

更新日期：2017-01-01 00:00:00